COMPARISON OF SAFETY OF LATANOPROST WITH PRESERVATIVE BENZALKONIUM CHLORIDE (BAK) VERSUS BAK-FREE TRAVOPROST IN PRIMARY OPEN-ANGLE GLAUCOMA
نویسندگان
چکیده
Objective: The objective of this study was to compare the safety BAK-preserved latanoprost versus travoprost BAK-free ophthalmic solution in primary open-angle glaucoma (POAG). Methods: Prospective, open-labeled, and randomized comparative conducted tertiary care hospital. Forty patients were enrolled divided into 20 each group: Group A topical (0.005%) with BAK B (0.004%). Safety assessment done by following parameters – Schrimer test (ST), tear break-up time (TBUT), ocular surface disease index (OSDI). Results: ST TBUT calculated at baseline, 1 month, 2 months, 3 4 months OSDI scores months. compared using ST, TBUT, scores. showed statistically significant results (p<0.05). Conclusion: Topical is more tolerable than latanoprostin POAG.
منابع مشابه
A comfort comparison of travoprost BAK-free 0.004% versus latanoprost 0.005% in patients with primary open-angle glaucoma or ocular hypertension
PURPOSE To determine the short-term comfort after a single dose of travoprost BAK-free compared to latanoprost in primary open-angle glaucoma or ocular hypertensive patients. DESIGN Prospective, double-masked, randomized comparison of two separate active agents dosed once in opposite eyes. METHODS At Visit 1, qualified patients began a glaucoma medicine-free period for three days. At Visit ...
متن کاملEfficacy, safety, and tolerability of travoprost 0.004% BAK-free versus prior treatment with latanoprost 0.005% in Japanese patients
OBJECTIVE To examine the efficacy, safety, and tolerability of travoprost 0.004% benzalkonium chloride (BAK)-free compared with previous use of latanoprost 0.005% in Japanese patients living in the US who had primary open-angle glaucoma or ocular hypertension. METHODS This was an open-label, multicenter, bilateral, intraindividual, and active-controlled study in which 20 Japanese American pat...
متن کاملOcular surface disease in patients with glaucoma or ocular hypertension treated with either BAK-preserved latanoprost or BAK-free travoprost
PURPOSE The preservative benzalkonium chloride (BAK) may adversely affect ocular surface health. This study evaluated symptoms of ocular surface disease (OSD) in patients previously treated with a BAK-preserved therapy to lower their intraocular pressure, who either continued that therapy or switched to a BAK-free therapy. METHODS Eligible adult patients with ocular hypertension or open-angle...
متن کاملEfficacy and tolerability of benzalkonium chloride-free travoprost in glaucoma patients switched from benzalkonium chloride-preserved latanoprost or bimatoprost
INTRODUCTION The preservative benzalkonium chloride (BAK) is used to preserve several topical, intraocular pressure (IOP)-lowering glaucoma medications but can cause tolerability concerns that may lead to decreased adherence to treatment and ultimately diminish the effectiveness of IOP control. The study aimed to determine the efficacy and tolerability of BAK-free travoprost preserved with poly...
متن کاملEffectiveness of ophthalmic solution preservatives: a comparison of latanoprost with 0.02% benzalkonium chloride and travoprost with the sofZia preservative system
BACKGROUND Although in vitro and in vivo laboratory studies have suggested that benzalkonium chloride (BAK) in topical ophthalmic solutions may be detrimental to corneal epithelial cells, multiple short- and long-term clinical studies have provided evidence supporting the safety of BAK. Despite the conflicting evidence, BAK is the most commonly used preservative in ophthalmic products largely d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical and Clinical Research
سال: 2022
ISSN: ['0974-2441', '2455-3891']
DOI: https://doi.org/10.22159/ajpcr.2022.v15i7.44829